Key result
Rat InsP3R2 C-terminal and cytoplasmic domains interact with themselves and InsP3R1 and InsP3R3 C-termini.
Population
Rat inositol 1,4,5-trisphosphate receptor isoform 2 (InsP3R2) and yeast two-hybrid assay models
Design
Preclinical
Authors
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Should not yet inform clinical practice; leaves open roles in cardiac calcium signaling.
The study identifies specific self-interactions in the C-terminal and upstream transmembrane domains of rat InsP3R2, advancing the understanding of calcium channel oligomerization.
Magnino et al. (2001) studied this question. The C-terminal domain and the cytoplasmic part preceding the first transmembrane domain of rat InsP3R2 interact with themselves and with the C-termini of InsP3R1 and InsP3R3.
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