Key result
Chimeric porcine deltacoronavirus from Vietnam induces clinical disease and villus atrophy in young pigs.
Why the study?
Phylogenetic analyses suggested that Vietnam porcine deltacoronavirus is a chimeric virus, prompting retrospective investigation of its presence and genome characterization.
Population
Six PDCoV isolates identified in 2014-2016 and three-day-old pigs in Vietnam
Design
Retrospective and preclinical viral challenge study
Authors
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May signal emerging swine health threats from chimeric PDCoV; leaves open needs for surveillance and intervention studies.
Observational (n=6)
Vietnam PDCoV is genetically diverse, includes chimeric strains resulting from recombination with US isolates, and is pathogenic in young pigs.
Saeng‐chuto et al. (2019) conducted an observational in Porcine deltacoronavirus (PDCoV) infection (n=6). Chimeric porcine deltacoronavirus (PDCoV) was evaluated on Viral infectivity and pathogenicity (clinical diseases and villus atrophy). Chimeric porcine deltacoronavirus isolates from Vietnam demonstrated genetic diversity and induced clinical disease and villus atrophy in challenged three-day-old pigs.
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