Visual field constriction in children treated with vigabatrin

Over the last 2 years, an increasing number of articles have been published reporting visual field constrictions (VFC) in adult patients on vigabatrin therapy.1-3 Although vigabatrin is indicated as the primary antiepileptic drug (AED) for infantile spasms, and as an add-on therapy for other complicated childhood epilepsies,4 there are no reports on possible VFC in epileptic children treated with vigabatrin. We report two pediatric patients with epilepsy who after receiving vigabatrin treatment showed VFCs consistent with those previously reported in adult patients. This 10-year-old girl with symptomatic, longstanding complex partial epilepsy had onset at 30 months of age. Previous AED treatments consisted of monotherapy with carbamazepine, oxcarbazepine, or sodium valproate. For the last 33 months, she has received vigabatrin 2,500 to 2,750 mg/day, for the first 5 months together with carbamazepine. Neuroradiologic examinations have shown enlarged cisterna magna, fourth ventricle and temporal horns of the lateral ventricles, and vermis hypoplasia. The patient had no neurologic disabilities or subjective …