Key result
Hemodialysis was associated with a significantly higher burden of depressive disorder and lower quality of life compared to peritoneal dialysis in patients with chronic kidney disease.
Why the study?
Depressive illness in chronic kidney disease is an independent risk factor for morbidity and mortality, with a complex relation to quality of life.
How does the burden of depressive illness and quality of life compare among CKD patients on hemodialysis, peritoneal dialysis, and conservative medical management?
Cross-Sectional
How does the burden of depressive illness and quality of life compare among CKD patients on hemodialysis, peritoneal dialysis, and conservative medical management?
There is a significant burden of depressive illness in CKD patients, with hemodialysis patients experiencing higher rates of depression and lower quality of life compared to those on peritoneal dialysis.
HD patients may warrant closer depression monitoring than PD; hypothesis-generating for modality effects on QoL in CKD.
BACKGROUND: Depressive illness in chronic kidney disease (CKD) is an independent risk factor for morbidity and mortality. The relation between depressive illness and quality of life (QoL) in this vulnerable group is complex. We attempted to study the burden of depressive illness, the QoL in patients of CKD on hemodialysis (HD), and peritoneal dialysis (PD) as well as those who were not on any dialysis but on conservative medical management only. MATERIALS AND METHODS: Observational study with cross-sectional analytical controlled design. STATISTICAL METHODS USED: <0.05 was considered as statistically significant. RESULTS: Depressive symptoms were present significantly across all 3 groups of CKD patients. Depressive disorder was significantly higher in the HD group. Mean QoL was significantly better in patients of CKD on PD. DISCUSSION: There is huge hidden burden of depressive symptoms and depressive illness in patients of CKD whether on dialysis or on conservative medical management. The study found significantly higher burden of depressive illness and lower QoL among the HD vis a vis PD patients, even though the majority of our CKD who require dialysis are on HD. CONCLUSION: Depressive burden is the hidden factor behind poor QoL, poor overall satisfaction as well as treatment outcome in patients of CKD whether or not on dialysis. To address this hidden depressive burden comprehensively, close cooperation between nephrologist and psychiatrist is called for.
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Prasad et al. (2019) conducted a cross-sectional in Chronic kidney disease (CKD). Hemodialysis vs. Peritoneal dialysis and conservative medical management was evaluated on Depressive illness and quality of life. Hemodialysis was associated with a significantly higher burden of depressive disorder and lower quality of life compared to peritoneal dialysis in patients with chronic kidney disease.
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