Waldenstrom macroglobulinemia (WM) is characterized by bone marrow (BM) infiltration of monoclonal Immunoglobulin M (IgM) secreting lymphoplasmacytic lymphoma (LPL), and typically presents with anemia. MYD88 and CXCR4 activating somatic mutations ( CXCR4MUT ) are common in WM, and found in 90–95
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Vos et al. (2017) studied this question.
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