Key result
A decline in estimated glomerular filtration rate showed a positive clinical correlation with reduced left ventricular ejection fraction, though this relationship did not reach statistical significance (Spearman's rho 0.097, p=0.162).
Why the study?
Data were limited regarding the relationship between the severity of left ventricular dysfunction and renal function impairment in diabetic patients.
Cross-Sectional (n=220)
No
Effect estimate: Spearman's correlation coefficient 0.097
p-value: p=0.162
In patients with type 2 diabetes for over 5 years, declining renal function is clinically associated with reduced left ventricular ejection fraction and significantly correlated with regional wall motion abnormalities and diastolic dysfunction.
Non-significant eGFR-LVEF correlation in longstanding T2DM; hypothesis-generating for cardiorenal links, should not yet change practice.
Background: There is paucity of data regarding the relationship between the severity of left ventricular dysfunction and renal function impairment in diabetic patients. Aims and objectives was to study the relation between eGFR and ejection fraction in type 2 diabetes mellitus of more than 5 years duration.Methods: This cross sectional was carried out from May 2017 to May 2018 at Yenepoya Medical college a tertiary care center in the southern Indian state of Karnataka. The data on 220 diabetic patients were studied. A detailed clinical history physical examination was carried out on the study population as per the approved proforma. Apart from base line investigations, eGFR was calculated using serum creatinine levels. 2D echocardiography was done for the assessment of ventricular function.Results: Out of 220 patients, 138 were men (63%) and 82 were women (37%) and the mean age of the patients was 59.60±11.145 years. The mean duration of diabetes was 10.08±5.28 years. We found a progressive reduction in ejection fraction from 57.74±9.97% to 50.64±14.7 as the eGFR declined from <90 mL/min/1.73m2 to 30 mL/min/1.73m2. There was significant correlation between eGFR and RWMA (p value 0.001) and LVDD (p value 0.029) in this study cohort. Micro/macroalbuminuria was found to be in 55% of patients. Proteinuria had significant correlation with longer duration of diabetes, blood urea, serum creatinine and eGFR.Conclusions: This study found positive clinical correlation between LVEF and eGFR. However, it did not reach significant levels statistically. Further studies may be carried out to confirm the association.
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P. et al. (2020) conducted a cross-sectional in Type 2 diabetes mellitus (n=220). Estimated glomerular filtration rate (eGFR) vs. Higher eGFR levels was evaluated on Correlation between eGFR and left ventricular ejection fraction (Spearman's correlation coefficient 0.097, p=0.162). A decline in estimated glomerular filtration rate showed a positive clinical correlation with reduced left ventricular ejection fraction, though this relationship did not reach statistical significance (Spearman's rho 0.097, p=0.162).
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