We have found in our stock cultures of clinical origin Providencia strains that were resistant to various aminoglycoside antibiotics including lividomycin and the gentamicin C complex but sensitive to kanamycin A and a new kanamycin A derivative, BB-K8.The substrate profile of inactivation of aminoglycosides combined with structural studies of the inactivated product of 3'-deoxyparomamine, indicate that aminoglycosides were inactivated by acetylation of the amino group at the 2'-C position.
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Yamaguchi et al. (1974) studied this question.