Gastric Lymphoma: The Revolution of the Past Decade

BACKGROUND: Gastric MALT type lymphomas are distinct lymphomas that may develop after chronic antigenic stimulation caused by infection with Helicobacter pylori. An early antigen-dependent phase precedes the development of an antigen-independent phase. METHODS: Narrative review. RESULTS: The causative relationship between a chronic H. pylori infection and gastric MALT lymphomas has been based on epidemiological, histological, experimental and therapeutic studies. H. pylori eradication leads to a histological remission in +/- 70% of patients in early stage low-grade MALT lymphoma. There is no basis for therapeutic consequences in the case of persistent monoclonality. Full thickness invasion of the gastric wall and lymph node involvement and/or high-grade lymphoma denote the transition to an antigen-independent phase and calls for conventional treatment modalities. Molecular findings show a specific translocation in low-grade MALT lymphomas: t(11,18) and nuclear expression of bcl-10 that are highly indicative of the transition of the antigen-dependent into the antigen-independent phase. Other chromosomal and molecular findings are probably also involved. CONCLUSION: The multistep pathogenesis of chronic H. pylori gastritis into low-grade gastric MALT lymphoma and tumour progression to a higher stage and grade are characterized by multiple molecular biological events. Antigen-dependency during the early phase of this malignancy is proven by the results of H. pylori eradication.