The effect of tazobactam on the piperacillin susceptibility and on the beta-lactamase activity of different strains and species was evaluated. A synergistic effect was observed on the piperacillin susceptibility for all microorganisms tested, irrespective of the type and/or amount of beta-lactamase produced. Addition of gentamicin resulted in a further reduction of the piperacillin MIC. The enzyme activity after induction with piperacillin alone or in combination with tazobactam (4 mg/l) was quite similar.
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E.E. Stobberingh (2009) studied this question.