Key result
Smoking is linked to greater PAI-1 and blunted NO increases after phlebotomy versus non-smokers.
Why the study?
Does smoking alter the endothelial response (PAI-1 and NO levels) to phlebotomy in healthy blood donors?
Population
88 healthy blood donors (48 smokers and 40 non-smokers)
Comparison
Smoking and phlebotomy vs Non-smokers
Design
Cohort
Follow-up
Acute (after phlebotomy)
Authors
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Smoking may signal early endothelial dysfunction in donors; hypothesis-generating and should not yet change practice.
Observational (n=88)
Does smoking alter the endothelial response (PAI-1 and NO levels) to phlebotomy in healthy blood donors?
Smoking is associated with an impaired fibrinolytic and blunted nitric oxide response to phlebotomy in healthy blood donors, indicating early subclinical endothelial dysfunction.
Büyükhatipoğlu et al. (2009) conducted an observational in Healthy blood donors (n=88). Cigarette smoking vs. Non-smokers was evaluated on Plasminogen activator inhibitor-1 (PAI-1) and nitric oxide (NO) levels after phlebotomy. Cigarette smoking in 48 healthy blood donors was associated with a more pronounced increase in PAI-1 and a blunted increase in NO following phlebotomy compared to 40 non-smokers.
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