Key result
Radical resection of cutaneous angiosarcoma in chronic lymphedema precedes fatal metastatic recurrence at 7 months.
Case Report (n=1)
No
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This case highlights the rare occurrence of cutaneous angiosarcoma in a chronically lymphedematous abdominal panniculus due to morbid obesity.
Herein, we report a case of cutaneous angiosarcoma in a 35-year-old, morbidly obese woman. The tumor arose in the most dependent portion of the lower abdominal panniculus and showed typical changes of chronic lymphedema. The patient underwent a radical resection of her lower abdominal wall panniculus, which showed a multicentric, high-grade angiosarcoma with bilateral superficial inguinal lymph node metastases. Histologically, conventional vasoformative areas were admixed with poorly differentiated sheets of spindle and epithelioid cells. Factor VIII was focally positive (membranous), whereas CD31 showed robust, diffuse positivity (membranous and cytoplasmic). The initial margins of resection were negative, and no follow-up radiation or chemotherapy was given. Following a recurrence at the previous excision site, the patient died 7 months after the surgery. Postmortem examination revealed a widely metastatic tumor that involved multiple organ systems. We believe this is the second report of cutaneous angiosarcoma occurring in a chronically lymphedematous abdominal panniculus due to morbid obesity.
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Azam et al. (2001) conducted a case report in Cutaneous angiosarcoma (n=1). Radical resection was evaluated. Radical resection of a cutaneous angiosarcoma in a chronically lymphedematous abdominal panniculus was followed by fatal metastatic recurrence 7 months post-surgery in a 35-year-old woman.
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