The use of gas chromatography with headspace sampling is commonplace in analytical laboratories for the analysis of residual solvents. In this article, we discuss the use of an internal standard-based calibration, utilizing relative response factors, to enable the generation of accurate weight % solvent data on 25 common solvents in a single chromatographic run. The total cycle time for analysis is less than 30 min. To facilitate this technology into the process chemistry environment, bespoke open access software has been developed to simplify the sample submission process such that virtually no training is required to analyze the sample, process the data, and generate a report. Furthermore, an automated calibration check workflow has been implemented to validate the quality of the data on a daily basis and alert the system administrator in the event of a problem with the system.
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Hamilton et al. (2016) studied this question.
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