Small and selective: A synthetically assembled CXCR4 mimetic peptide, which presents the three extracellular loops (ECLs) of this HIV-1 co-receptor, is able to discriminate between gp120 from X4- and R5-tropic HIV-1 in binding assays involving recombinant proteins, as well as in cellular infection assays.
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Möbius et al. (2012) studied this question.
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