Why the study?
NT-proBNP is involved in the pathophysiology of heart failure, prompting investigation into its correlation with routine blood test results.
Cross-Sectional (n=184)
No
NT-proBNP levels are significantly correlated with routine blood parameters, most notably renal function (creatinine), which must be considered when interpreting this biomarker for heart failure.
This study investigated retrospectively the correlation between the results of the N-terminal pro-brain natriuretic peptide (NT-proBNP) and a routine blood test using a hospital information system.The NT-proBNP is involved in the pathophysiology of heart failure.The results show that the relationship between age and NT-proBNP was significant (P＜0.01) with a positive correlation (r=0.163).The peptide concentration showed a negative correlation between the total protein (r= -0.250) and albumin (r=-0.270),and a negative correlation between the erythrocyte count and hemoglobin and hematocrit (P＜0.01).NT-proBNP had a positive correlation with neutrophils (r=0.227) and a negative correlation with lymphocytes (r=-0.236),showing significant results (P＜0.01).NT-proBNP and creatinine showed a positive correlation (r=0.594,P＜0.01), and it was the most influential factor according to multiple regression analysis (B=0.53, t=7.65).P＜0.01).The concentrations of NT-proBNP and uric acid showed a positive correlation (r=0.180,P＜0.05).Lactate dehydrogenase was observed as a factor affecting the NT-proBNP (B=0.20,t=3.28,P＜0.01).This explanatory power had an influence of 43%.Therefore, the accurate test and related factors of the NT-proBNP have significant clinical value.
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Park et al. (2020) conducted a cross-sectional in Emergency room patients (n=184). Routine blood test factors (creatinine, LDH) was evaluated on Correlation between NT-proBNP and creatinine (r=0.594, p=<0.01).
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