The preorganized presentation of functional groups in the antibiotic neomycin (green) is exploited to obtain a conformationally restricted aminoglycoside (yellow) by regioselective intramolecular cyclization. X-ray crystallography data show how the natural product and the derivative recognize the RNA target motif that is the binding site of aminoglycoside antibiotics.
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Zhao et al. (2005) studied this question.
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