Nucleotides. Part XXXV. Synthesis of 3′‐deoxyadenylyl‐(2′–5′)‐3′‐deoxyadenyIyl‐(2′–ω)‐9‐(ω‐hydroxyalkyl)adenines

Via the phosphotriester approach, new structural analogs of (2′–5′)oligoadenyiates, namely 3′‐deoxyadenylyl‐(2′–5′)‐3′‐dcoxyadenylyl‐(2′–ω)‐9‐(ω‐hydroxyalkyl)adenines 18–21, have been synthesized (see Scheme) which should preserve biological activity and show higher stability towards phosphodiesterases. The newly synthesized oligonucleotides 18–21 have been characterized by 1H‐NMR spectra, TLC, and HPLC analysis.