Scleromyxoedema: a cause for unexplained encephalopathy and myositis

We report a 44-year-old man who presented with recurrent unexplained encephalopathy and myositis despite extensive neurological and metabolic investigations. Eventually, he was noted to have multiple asymptomatic flesh-coloured papules suggestive of scleromyxoedema, which was confirmed by histology. Although primarily a cutaneous disease, extracutaneous features of scleromyxoedema may dominate the clinical picture of this rare mucin-deposition disorder.