Synthesis, Identification and Evaluation the Biological Activity for Some New Heterocyclic Compounds Derived from Schiff Bases

This research involves synthesis some of new tetrazole, imidazolinone, thiazolidinone, and oxazepine derivatives.The first step includes formation Schiff bases (1-5) from condensation N-[(4-aminophenyl) carbamothioyl] benzamide with different aromatic aldehydein the presence of glacial acetic acid in DMF as a solvent.Four route with different reagents used for the cyclization of the prepared Schiff bases by reagent (sodium azide, 2-amino acetic acid, 2-mercapto acetic acid and phthalic anhydride) to form tetrazole (6-10), imidazolinone (11-15), Thiazolidinone (16-20), oxazepine(21-25) derivatives respectively.The structure of newly synthesized compounds were identified by spectral methods their [FTIR, and some of them by 1HNMR, 13C-NMR] and measurements some of its physical properties and some specific reactions.The chemical structures of synthesized compounds were well characterized by 1HNMR, 13CNMR, FT-IR and TLC.Also, the effects of prepared compounds in some of strains of bacteria were studied.