The significance of the antidepressants' serotonin-potentiating properties in relationship to the therapeutic effect has been one of the key research areas within depression during the last decades.On this basis a number of drugs with more selective influence on the serotonin system has been developed and the following study is a controlled clinical evaluation of femoxetine, a phenylpiperidine derivative with potent serotonin-potentiating properties in patients suffering from a depressive illness.
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Ahlberg et al. (1982) studied this question.
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