Pneumonitis Associated with Nonsteroidal Antiandrogens: Presumptive Evidence of a Class Effect

Letters1 October 2002Pneumonitis Associated with Nonsteroidal Antiandrogens: Presumptive Evidence of a Class EffectCharles L. Bennett, MD, PhD, Dennis W. Raisch, PhD, and Oliver Sartor, MDCharles L. Bennett, MD, PhDVeterans Affairs Chicago Healthcare System/Lakeside Division; Chicago, IL 60611 (Bennett)University of New Mexico; Albuquerque, NM 87047 (Raisch)Louisiana State University; New Orleans, LA 70112 (Sartor), Dennis W. Raisch, PhDVeterans Affairs Chicago Healthcare System/Lakeside Division; Chicago, IL 60611 (Bennett)University of New Mexico; Albuquerque, NM 87047 (Raisch)Louisiana State University; New Orleans, LA 70112 (Sartor), and Oliver Sartor, MDVeterans Affairs Chicago Healthcare System/Lakeside Division; Chicago, IL 60611 (Bennett)University of New Mexico; Albuquerque, NM 87047 (Raisch)Louisiana State University; New Orleans, LA 70112 (Sartor)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-7-200210010-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Hypersensitivity pneumonitis, a serious pulmonary disease that is caused by many drugs, is associated with mortality rates of less than 1% (1, 2). Nilutamide, a nonsteroidal antiandrogen used for prostate cancer treatment, is a common cause of hypersensitivity pneumonitis, with reported rates of 1% to 2% (2). For all drugs, diligent postmarketing surveillance is required to ensure drug safety. To date, one case of pneumonitis with bicalutamide and one with flutamide have been reported (3, 4).We reviewed all cases of pneumonitis associated with bicalutamide, flutamide, and nilutamide reported in MedWatch, the U.S. Food and Drug Administration's ...References1. Cooper JA. Advances in Internal Medicine. St. Louis: Mosby–Year Book; 1997:231-68. Google Scholar2. McLeod DG. Tolerability of Nonsteroidal Antiandrogens in the Treatment of Advanced Prostate Cancer. Oncologist. 1997;2:18-27. [PMID: 10388026] CrossrefMedlineGoogle Scholar3. Wong PW, Macris N, DiFabrizio L, Seriff NS. Eosinophilic lung disease induced by bicalutamide: a case report and review of the medical literature. Chest. 1998;113:548-50. [PMID: 9498983] CrossrefMedlineGoogle Scholar4. Azuma T, Kurimoto S, Mikami K, Oshi M. Interstitial pneumonitis related to leuprorelin acetate and flutamide. J Urol. 1999;161:221. [PMID: 10037405] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Charles L. Bennett, MD, PhD; Dennis W. Raisch, PhD; Oliver Sartor, MDAffiliations: Veterans Affairs Chicago Healthcare System/Lakeside Division; Chicago, IL 60611 (Bennett)University of New Mexico; Albuquerque, NM 87047 (Raisch)Louisiana State University; New Orleans, LA 70112 (Sartor) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPneumonitis with Antiandrogens Syed Rizwanuddin Ahmad and David J. Graham Pneumonitis with Antiandrogens Charles L. Bennett and Oliver Sartor Metrics Cited byDetecting drug-drug interactions between therapies for COVID-19 and concomitant medications through the FDA adverse event reporting systemHormone Treatment of Prostate Cancer:Recovery From Bicalutamide-Associated Pneumonitis in a Patient With ATM -Deficient Prostate CancerSuccessful recovery from multiple organ failure associated with bicalutamide and leuprorelin acetate for prostate cancerAdverse reactions to oncologic drugs: spontaneous reporting and signal detectionResults from the First Decade of Research Conducted by the Research on Adverse Drug Events and Reports (RADAR) ProjectFamilial Male-Limited Precocious PubertyPneumonitis with Antiandrogens Severe Hypersensitivity Pneumonitis with Anagrelide Adverse Reactions to a New Food Ingredient Psychiatric Adverse Events with Levetiracetam Levofloxacin-Induced Hemolytic Anemia Levofloxacin and Achilles Tendon RuptureDissemination of Information on Potentially Fatal Adverse Drug Reactions for Cancer Drugs From 2000 to 2002: First Results From the Research on Adverse Drug Events and Reports ProjectPneumonitis with AntiandrogensSyed Rizwanuddin Ahmad, MD, MPH and David J. Graham, MD, MPHNews in brief ... 1 October 2002Volume 137, Issue 7Page: 625KeywordsDrug safetyDrugsDyspneaFood and Drug AdministrationHepatitisHypersensitivityPneumonitisProstate cancerPulmonary diseasesVision ePublished: 1 October 2002 Issue Published: 1 October 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...