Metabolism in Vitro of Adipose Tissue in Obese-hyperglycemic and Goldthioglucose-treated Mice

Although obesity implies excessive storage of fat in adipose tissue, the possibility that a metabolic anomaly of this tissue might underlie at least certain forms of obesity has received relatively little attention.Recent emphasis in several laboratories upon the importance of adipose tissue as a site of metabolic homeostasis for carbohydrates and fats clearly suggests that a re-evaluation of this possible mechanism for the production of obesity is in order.For the initial study of this series, the authors have selected two types of obesity in mice, both rather clearly defined and etiologically distinct.