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September 12, 2026BMC BiologyOpen Access

Effect of hypoxia and reoxygenation on the nervous system of the Mediterranean mussel Mytilus galloprovincialis

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Authors

TGTosca Agneta van GelderenEDEnrico D’AnielloAMAlberto Macina

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Overview

Laboratory study reveals cellular and transcriptomic neuroadaptations to oxygen shifts in Mediterranean mussels, highlighting mechanisms driving invertebrate environmental resilience.

Key Points

  • To characterize the cellular, transcriptomic, and microRNA-mediated regulatory mechanisms that allow the nervous system of Mytilus galloprovincialis to adapt to fluctuating oxygen levels.
  • Performed histochemical analysis of individual ganglia in Mediterranean mussels exposed to hypoxia and reoxygenation cycles.
  • Conducted transcriptomic and miRNomic sequencing on pedal ganglia tissue to identify adaptive gene networks and microRNA expression profiles.
  • Catecholaminergic, peptidergic, and serotonergic neurons within the pedal ganglia demonstrated homeostatic plasticity in response to oxygen fluctuations.
  • Transcriptomic profiling identified adaptive candidate genes controlling cellular homeostasis, cell survival, cell proliferation, and mitochondrial function.
  • miRNome profiling revealed no significant changes in mature microRNA expression during hypoxia and reoxygenation cycles.

Cite This Study

Gelderen et al. (2026) studied this question.

synapsesocial.com/papers/6aa51e9d327956e4761f87cbhttps://doi.org/10.1186/s12915-026-02731-3
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