Protective Effects of Esculetin at two Different Doses on Oxidative Stress, Inflammation, and Fibrotic Changes in AlCl₃-Induced Cardiotoxicity in Rats

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Esculetin exerts protective effects against aluminum chloride-induced cardiotoxicity in rats by mitigating oxidative stress, inflammation, and fibrotic changes. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Tansu Kuşat; Feyza Başak; Orhan Önalan; Ali Şenol

doi:10.5798/dicletip.2037192

September 10, 2026Dicle Medical Journal / Dicle Tip DergisiOpen Access

Protective Effects of Esculetin at two Different Doses on Oxidative Stress, Inflammation, and Fibrotic Changes in AlCl₃-Induced Cardiotoxicity in Rats

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Key Points

To evaluate the protective efficacy of two different doses of esculetin against aluminum chloride-induced cardiotoxicity, oxidative stress, inflammation, and fibrotic remodeling.
35 male Wistar albino rats were randomly assigned to five equal groups (n=7 per group): Control, Vehicle, AlCl₃ (10 mg/kg), AlCl₃ + esculetin (50 mg/kg), and AlCl₃ + esculetin (100 mg/kg).
Treatments were administered orally once daily over a 14-day intervention period.
Cardioprotective effects were evaluated via oxidative stress biomarkers (MDA, GSH, SOD, CAT), pro-inflammatory cytokines (TNF-α, IL-1β), histopathology, and immunohistochemistry for iNOS and α-SMA.
Exposure to AlCl₃ significantly elevated cardiac tissue MDA and depleted GSH, accompanied by marked suppression of SOD and CAT enzymatic activities.
AlCl₃ treatment stimulated cardiac inflammatory and fibrotic cascades, evidenced by elevated TNF-α and IL-1β alongside increased immunoreactivity for iNOS and α-SMA.
Esculetin co-administration reversed oxidative damage, attenuated inflammatory markers, and suppressed fibrotic remodeling in a dose-dependent manner.

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Implication

Controlled animal study demonstrates that esculetin mitigates oxidative stress, inflammation, and fibrosis in aluminum-exposed rats, highlighting its dose-dependent cardioprotective potential.

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Kuşat et al. (2026) studied this question.

synapsesocial.com/papers/6aa51ebf327956e4761f892b https://doi.org/10.5798/dicletip.2037192

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Protective Effects of Esculetin at two Different Doses on Oxidative Stress, Inflammation, and Fibrotic Changes in AlCl₃-Induced Cardiotoxicity in Rats

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Protective Effects of Esculetin at two Different Doses on Oxidative Stress, Inflammation, and Fibrotic Changes in AlCl₃-Induced Cardiotoxicity in Rats

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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