In vitro study reveals distinct transcriptional responses to anthelmintics in human enterocytes, suggesting differential host cell pathways are altered during treatment.
Key Points
To determine how three common anthelmintic drugs—albendazole, ivermectin, and praziquantel—alter gene expression profiles in human intestinal enterocytes.
Cultured human intestinal epithelial cells (FHs 74 Int) were exposed for 24 hours to albendazole (1 µM), ivermectin (15 µM), or praziquantel (1 mM).
Cytotoxicity was assessed at 24 and 72 hours, followed by transcriptome profiling using criteria of adjusted p-value (padj) ≤ 0.05 and log2 fold change thresholds.
Praziquantel (1 mM) caused negligible cytotoxicity and induced zero significant transcriptional changes at padj ≤ 0.05 and log2 fold change ≥ 0.