What is the clinical evidence from this study?

Study design: RCT. Population: Heart disease. Intervention: Multifactorial intervention vs. Control. Primary outcome: Total mortality and CHD incidence.

What does this research mean for the field?

Multifactorial cardiovascular risk reduction initially reduces total mortality and CHD incidence in middle-aged men, but mortality benefits attenuate over long-term follow-up unless risk factor reductions are maintained. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the long-term impact of a 6-year multifactorial intervention on total and cause-specific mortality after 10 years of follow-up in middle-aged men.

March 1, 1988European Heart Journal

The Belgian Heart Disease Prevention Project: 10-Year mortality follow-up

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Key result

Multifactorial intervention initially lowers mortality and CHD but benefits attenuate by 10 years.

Why the study?

Does a multifactorial intervention reduce total mortality and CHD incidence in middle-aged men?

Population

Middle-aged men

Comparison

Multifactorial intervention lasting 6 years vs Control group

Design

RCT, randomized

Follow-up

10 years

Authors

GBGuy De BackerGhent University Hospital MKMarcel KornitzerUniversity College Dublin MDM. DramaixUniversité Libre de Bruxelles

Discussion

Member takes

Implication

Long-term continuation of multifactorial intervention is required to sustain mortality benefit; extends RCT evidence on durability beyond active treatment.

Key Points

To evaluate the long-term impact of a 6-year multifactorial intervention on total and cause-specific mortality after 10 years of follow-up in middle-aged men.
Controlled, randomized multifactorial intervention trial in middle-aged men spanning an active 6-year intervention period.
Systematic follow-up of total and cause-specific mortality from year 6 to year 10, achieving 99.3% follow-up completeness.
Net differences in risk profile change, total mortality, and coronary heart disease incidence favored the intervention group during the trial, peaking at two years and becoming minimal by year six.
Differences between the intervention and control groups for total, coronary, and cardiovascular mortality narrowed markedly between the 6th and 10th years.

Study Design

Type

RCT

Randomization

randomized

Structured PICO

Does a multifactorial intervention reduce total mortality and CHD incidence in middle-aged men?

Population

Middle-aged men followed for 10 years to assess the impact of a multifactorial intervention on mortality and CHD incidence.

Intervention

Multifactorial intervention lasting 6 years

Comparator

Control group

Outcome

Total mortality and CHD incidencehard clinical

Multifactorial risk reduction interventions in middle-aged men must be maintained long-term to sustain reductions in cardiovascular mortality.

Cite This Study

Backer et al. (1988) conducted an RCT in Heart disease. Multifactorial intervention vs. Control was evaluated on Total mortality and CHD incidence. A multifactorial intervention in middle-aged men initially reduced total mortality and CHD incidence, but the differences between groups attenuated by the 10-year follow-up.

synapsesocial.com/papers/6aa52160affc7bfe5364adab https://doi.org/10.1093/oxfordjournals.eurheartj.a062491

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Implication

Long-term continuation of multifactorial intervention is required to sustain mortality benefit; extends RCT evidence on durability beyond active treatment.

The Belgian Heart Disease Prevention Project: 10-Year mortality follow-up

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

The Belgian Heart Disease Prevention Project: 10-Year mortality follow-up

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

Also Consider