Key result
Surgical resection of renal cell carcinoma resolves jaundice and liver dysfunction in Stauffer's syndrome variant.
Case Report (n=1)
Surgical resection of renal cell carcinoma can reverse paraneoplastic cholestatic jaundice (Stauffer's syndrome variant).
Cholestasis, as a paraneoplastic syndrome, has been well described in patients with malignant lymphohyperplastic diseases and renal cell cancer. Non-metastatic nephrogenic hepatic dysfunction syndrome without jaundice has often been described in patients with Stauffer's syndrome. Paraneoplastic cholestatic jaundice is extremely uncommon. We report, a patient who presented with pruritus and cholestatic jaundice and was diagnosed with renal cell carcinoma (RCC) in the right kidney. Liver malfunction and cholestatic icterus was attributed to RCC. Jaundice and liver dysfunction gradually restored to normal after surgical resection of the tumor. Malignancies may cause cholestatic jaundice through well-recognized mechanisms. Paraneoplastic syndromes associated with malignancy, can induce a reversible form of cholestasis through an unclear pathogenetic mechanism.
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Giannakos et al. (2005) conducted a case report in Renal cell carcinoma with Stauffer's syndrome variant (n=1). Surgical resection of the tumor was evaluated on Resolution of jaundice and liver dysfunction. Surgical resection of renal cell carcinoma resulted in the gradual restoration of normal liver function and resolution of cholestatic jaundice in a patient with Stauffer's syndrome variant.
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