All articles of this category A short synthesis of (±)-γ-lycorane 6 is described using two different radical cyclisations. The key step is the formation of tetrahydroindolone 9 by a nickel-promoted 5-endo radical cyclisation. This is followed by a tributylstannane-mediated 6-endo ring closure to the tetracyclic lactam 10 which is readily reduced to (±)-γ-lycorane 6 . γ-lycorane - nickel - radical cyclisation
No takes yet. Share an insight, caveat, or question.
Cassayre et al. (1999) studied this question.