High Resolution Image Download MS PowerPoint Slide Four new triterpenoid bidesmosidic saponins ( 1 – 4 ) and a sesquiterpenoid glucoside ( 5 ), together with nine known phenolic compounds ( 6 – 14 ), were isolated from the fruits of Elaeagnus umbellata . Their structures were elucidated using 1D and 2D NMR spectroscopy and mass spectrometry data. The antioxidant capability of the isolated compounds was evaluated in human gingival fibroblasts. Compound 6 decreased ROS production and promoted cell proliferation. It also counteracted the cell cycle blockade induced by a low concentration of H 2 O 2 decreasing the expression of p21 and CDKN2A (p16 INK4A ). Compound 6 decreased the expression of inflammatory cytokines (IL-6 and IL-8) in response to inflammatory stimuli, supporting its possible use in periodontitis lesions.
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Iannuzzi et al. (2020) studied this question.
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