Key result
Lysozyme sensitization cuts mouse tail vein blood flow ~35% without altering blood pressure.
Population
Male ddY mice, 5 weeks old, sensitized subcutaneously with 50 mg of hen-egg white lysozyme in complete…
Comparison
Administration of various chemical mediator… vs HEL-sensitized mice without inhibitor treatment…
Design
Preclinical
Follow-up
9 days
Authors
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Should not change clinical practice; leaves open this mouse model for preclinical screening of allergy-preventive agents.
Absolute Event Rate: 65% vs 100%
p-value: p=<0.01
The study establishes a novel in vivo bioassay using HEL-induced tail vein blood flow decrease in mice to screen for allergy-preventive substances targeting NO, COX, and PGI2 pathways.
Ishiguro et al. (2005) studied Allergy (Hen-egg white lysozyme sensitization model). Hen-egg white lysozyme (HEL) sensitization vs. Non-treated normal mice was evaluated on Subcutaneous blood flow in the mouse tail vein (p=<0.01). Hen-egg white lysozyme sensitization in mice significantly decreased tail vein blood flow to 65-75% of normal by day 9 without altering blood pressure, providing a novel in vivo assay for allergy-preventive substances.
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