Profile of Transforming Growth Factor Beta 1 Gene (TGF- b1) Nucleotide 29 T869C Polymorphism in Malaysian Rheumatoid Arthritis patients

Introduction:Various studies on Rheumatoid arthritis (RA) patients suggested that polymorphism in the Transforming Growth Factor-Beta 1 (TGF- b1) gene may be associated with increased risk of RA severity. Results: Fifty-nine patients (52.68%%) were found to have non-severe disease and 53 patients (47.32%) were found to have severe disease. The frequency of CT genotype was the highest among the 3 genotypes (78 out of 112). For the Malays, 6 patients (12.5%) were CC genotype, 33 patients (68.7%) were CT genotype and 9 patients (18.8%) were TT genotype. For the Chinese, 7 patients (21.2%) were CC genotype, 22 patients (66.7%) were CT genotype and 4 patients (12.1%) were TT genotype. For the Indians, 5 patients (17.9%) were CC genotype, 20 patients (71.4%) were CT genotype and 3 patients (10.7%) were TT genotype. For the other ethnic groups, all 3 patients were CT genotype. Conclusion: CT genotype has the highest frequency (69.6%)