Effect of Dilantin Sodium Analogues on Cell Proliferation in Tissue Culture.

Several chemical analogues and chemically related compounds of Dilantin Sodium have been used to study and clarify the cell stimulatory effects of this compound. Two analogues (1 allyl, 5 phenyl hydantoinate and 5 methyl, 5 phenyl hydantoinate) induce stimulation of fibroblast-like cell proliferation while 2 other analogues (1 propyl, 5 phenyl hydantoinate and 3 methyl, 5,5 diphenyl hydantoinate) were completely ineffective. None of the other structurally related compounds tested (barbital sodium, urea, uric acid, alloxan, allantoin or hydantoin) produced any stimulation of cell proliferation.