Key result
Older women show lower resting skeletal muscle nutritive blood flow linked to eNOS protein content.
Cross-Sectional
Lower muscle eNOS protein content is correlated with lower skeletal muscle nutritive blood flow in healthy older women.
Lower nutritive muscle blood flow in older women correlates with eNOS content; hypothesis-generating for endothelial-targeted interventions in sarcopenia.
The relationship between muscle endothelial nitric oxide synthase (eNOS) content and nutritive flow was investigated in nonobese sedentary young (27.7 +/- 2.6 years) and older (56.6 +/- 2.1 years) women matched for body composition and (2)peak. A muscle biopsy was taken and nutritive blood flow was determined under resting conditions in the vastus lateralis of the quadriceps femoris muscle group. Muscle eNOS protein content correlated with muscle nutritive blood flow (r =.66, p <.05) and body mass index (r =.74, p <.05), but it did not correlate with VO(2)peak. Muscle eNOS content was 35% lower in young than in older women (266 +/- 36 vs 407 +/- 53 pg/mg total protein; p <.05). The mean ethanol outflow-to-inflow ratio was higher (indicating lower nutritive flow) in older and young women (.666 +/-.042 and.546 +/-.043, respectively: p <.05). Resting skeletal nutritive blood flow and muscle eNOS content was lower in older than in young women. A low muscle eNOS protein content may be linked to a low muscle nutritive blood flow in healthy women.
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Hickner et al. (2003) conducted a cross-sectional in Healthy nonobese sedentary women. Older age vs. Young age was evaluated on Mean ethanol outflow-to-inflow ratio (p=<.05). Older women had lower resting skeletal muscle nutritive blood flow (ethanol outflow-to-inflow ratio 0.666 vs 0.546; P<0.05), which correlated with muscle eNOS protein content.
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