Transient Reversal of Hyperabsorption of Calcium and of Abnormal Sensitivity to Vitamin D in a Patient with Sarcoidosis During Episode of Nephritis

Case Studies1 October 1964Transient Reversal of Hyperabsorption of Calcium and of Abnormal Sensitivity to Vitamin D in a Patient with Sarcoidosis During Episode of NephritisNORMAN H. BELL, M.D., FREDERIC C. BARTTER, M.D.NORMAN H. BELL, M.D.Search for more papers by this author, FREDERIC C. BARTTER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-4-702 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCalcium absorption is excessive in some patients with sarcoidosis and hypercalciuria and can be reversed with carbohydrate-active steroids (1-3) and enhanced with small doses of vitamin D (4-6). The abnormality of calcium metabolism was found to result from hypersensitivity to vitamin D (1, 3-6) and not from hypervitaminosis D (2). It has also been shown that the defect in calcium absorption in patients with renal failure is characterized by decreased absorption of calcium and probably by diminished responsiveness to vitamin D as well (7-9).This report describes a patient with sarcoidosis and abnormally increased absorption of calcium who developed glomerulonephritis...References1. ANDERSONDENTHARPERPHILPOTT JCECGR: Effect of cortisone on calcium metabolism in sarcoidosis and hypercalcemia, possible antagonistic actions of cortisone and vitamin D. Lancet 2: 270, 1954. Google Scholar2. HENNEMANDEMPSEYCARROLLALBRIGHT PHEFELF: The cause of hypercalciuria in sarcoid and its treatment with cortisone and sodium phytate. J. Clin. Invest. 35: 1229, 1956. CrossrefMedlineGoogle Scholar3. BELLGILLBARTTER NHJRFC: Calcium metabolism in sarcoidosis. Amer. Rev. Resp. Dis. 84: 27, 1961. MedlineGoogle Scholar4. MATHER G: Calcium metabolism and bone changes in sarcoidosis. Brit. Med. J. 1: 248, 1957. 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BERGERRELMAN KWAS: Renal impairment due to sarcoid infiltration of the kidney. Report of a case proved by renal biopsies before and after treatment with cortisone. New Eng. J. Med. 252: 44, 1955. CrossrefMedlineGoogle Scholar19. KESSNEREPSTEIN DMFH: The effect of uremia on the gastrointestinal transport of calcium (abstract). Clin. Res. 11: 245, 1963. Google Scholar20. SCHOLZKEATING DFR: Renal insufficiency, renal calculi, and neprocalcinosis in sarcoidosis. Amer. J. Med. 21: 75, 1956. CrossrefMedlineGoogle Scholar21. PHILLIPSFITZPATRICK RWDP: Steroid therapy of hypercalcemia and renal insufficiency in sarcoidosis. New Eng. J. Med. 254: 1216, 1956. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, MarylandFrom the Clinical Endocrinology Branch, National Institutes of Health, U. S. Public Health Service, Bethesda, Md. Requests for reprints should be addressed to Frederic C. Bartter, M.D., Clinical Endocrinology Branch, National Institutes of Health, U. S. Public Health Service, Bethesda, Md. 20014. 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ROBERT ARNSTEIN, M.D., BOY FRAME, M.D., F.A.C.P., HAROLD M. FROST, M.D.Granulomatous sarcoid nephritisAbnormal Skeletal Mineral Metabolism in SarcoidosisJAMES Z. HENDRIX, M.D. 1 October 1964Volume 61, Issue 4Page: 702-710KeywordsCalciumGlomerulonephritisHypersensitivityMedical servicesNephritisPrevention, policy, and public healthRenal failureSarcoidosisSteroidsVitamin D Issue Published: 1 October 1964 PDF downloadLoading ...