Studies on Melanin

predominance of female, it appears, perhaps depends on the cosmetic complaint.Type: Among 106 cases 45 were of mild orbital type, 22 were of mild zygomatic type, 19 were of moderate type, 10 were of intensive type (Plate VIII, Figure 30) 4 were of bilateral type, 3 were of each abortive and perinostril type, in brief mild type amounted to 2/3 of all cases.Location: The lesion was most found at upper and lower palpebra and next found on the temple, zygomatic region, cheek, forehead, etc.In comparison with the cutaneous innervation, 18 cases were found only in the 1st branch region (n.ophthalmicus), 27 in the 2nd branch region (n.maxillaris), 55 extended to the both regions, and 1 extended to the whole region from 1st to the 3rd branch, 1 ex tended widely to the 3rd branch, the 3rd and 4th cervical nerve and the 2nd thoracic nerve, and 3 were only found at the apex, ala nasi and nostril.By the way, in 1 case which attacked both 2nd and 3rd branch regions pale blue pigmentation was also found on the buccal mucous membrane.Side of lesion: 61 cases were on the right side, 39 on the left side and 6 cases were bilateral type.In comparing with type of lesion the difference between right and left side was scarcely found in the orbital type among mild type, but zygomatic moderate and intensive type are frequently found on the right side.From this it may be thought that there is any participation in the intrauterine position of fetus, but there is no significant difference between the 1st and 2nd attitude in the Japanese, so the factor which controls the side of lesion is not understood at all.Age of onset: In 65 cases the lesion appeared by birth or soon after birth and 41 cases were the delayed-type.About half cases among them were mild orbital type, so it seems that there were many one who found the nevus late, and 4 cases in which one could not distinguish the nevus without the attention because it became considerable in each puberty, 1 case in which the pigmented nevus became remarkable after marriage, 6 cases in which the conditions such as contusion or collision, etc. motived the nevus.Thus I can't deny the fact that the embryonal terrain which grows very slowly is promoted or strengthened under the physical dis harmony or some other inducement.Age of consultation: Like common nevus many consult in infant and in puberty and patients from 1 to 2 years amounted to 21 cases, from 14 to 20 years 28, from 21 to 25 years 32, from 26 to 30 years 9, from 31 to 40 years 8 and from 3 to 13 years only 4 cases.According to the types of lesion patients who consulted in 1 or 2 years of age were 31.02% in moderate and intensive cases, while in mild cases they amounted to almost half, that is 16.4% and it seems natural on account of the cosmetic com plaint that many patients of intensive type consult early in infancy.Color tone: Color tone was generally spotted color which consists of ephelide like brown and blue-nevuslike blue, and showed many tones of color, that is to say, black, blackpurple, blue black, deep blue, blue, fading blue, slate-blue, purplish brown, brown, and faint brown.This seems perhaps to depend on the healthy complexion and the quantity or the depth of pigmentation.The boundary was faint on account of fading in the periphery.These color tones scarcely changed after its perfection, but especially in female changes of the color tones were more or less seen according to the conditions such as menstruation or others.The observation of these changes was as follows ; in 10 cases the color tone of whom became dark * By Minor Ito .57