Diabetes Insipidus and ADH Regulation

The underlying biochemical defect in diabetes insipidus is a functional deficiency, or even a total absence, of ADH. The etiology ranges from congenital anomalies to malignant disease or even head trauma. With recognition that a number commonly used drugs either stimulate or inhibit ADH secretion and action, therapy of both diabetes insipidus and of inappropriate ADH secretion has been facilitated.