Cascade Assembling of Isatins and Barbituric Acids: Facile and Efficient Way to 2′′H‐Dispiro[indole‐3,5′‐furo[2,3‐d]pyrimidine‐6′,5′′‐pyrimidine]‐2,2′,2′′,4′,4′′,6′′‐(1H,1′H,1′′H,3′H,3′′H)‐hexone Scaffold

“One‐pot” transformation of isatins and barbituric acids by the direct action of the only bromine in ethanol results in the formation of substituted 2′′H‐dispiro[indole‐3,5′‐furo[2,3‐d]pyrimidine‐6′,5′′‐pyrimidine]‐2,2′,2′′,4′,4′′,6′′‐(1H,1′H,1′′H,3′H,3′′H)‐hexones in 70–87% yields via complex cascade process. Dispirobarbiturates containing spiro indole and furo[2,3‐d]pyrimidine framework are a class of compounds with prominent pharmacological and physiological activity. Thus, seven previously inaccessible 2′′H‐dispiro[indole‐3,5′‐furo[2,3‐d]pyrimidine‐6′,5′′‐pyrimidine]‐2,2′,2′′,4′,4′′,6′′‐(1H,1′H,1′′H,3′H,3′′H)‐hexones have been synthesized that represent the new class of dispirobarbiturates.