Key result
Preeclampsia is linked to a ~21-fold greater risk of peripartum cardiomyopathy.
Why the study?
To determine the characteristics of PPCM at RSUD Dr. Soetomo Hospital Surabaya and evaluate its relationship with preeclampsia.
Does preeclampsia increase the risk of peripartum cardiomyopathy in pregnant women?
Case-Control (n=2,843)
No
Does preeclampsia increase the risk of peripartum cardiomyopathy in pregnant women?
Preeclampsia is associated with a more than 20-fold increased risk of developing peripartum cardiomyopathy.
May prompt closer peripartum cardiomyopathy surveillance in preeclampsia; leaves open causality and requires prospective confirmation.
Objectives: To know the characteristic of PPCM in RSUD Dr. Soetomo Hospital Surabaya and to know the relationship between PPCM and PE.Materials and Methods: This was a case control study. Data was obtained from medical record of 2843 patients within 2014-2015, divided into 2 groups, 19 patients with PPCM in a case group, and 2824 patients in control group. The statistical analysis used was Fisher exact test.Results: Peripartum cardiomyopathy patients were older compared to control group (32.21 ± 6.83 y.o vs 29.26 ± 6.45 y.o). The incidence of PPCM in our study was about 1 per 149 live births. Most cases were diagnosed antepartum (52.63%), and about 84.2% PPCM cases were also complicating with preeclampsia. The statistical analysis revealed that there was increase risk of PPCM if the pregnant women complicates PE during pregnancy, with Odds Ratio (OR) 20.679, p<0.05. The most common perinatal outcomes was Small for Gestational Age (SGA) babies (81.8%), whereas case fatality rate (CFR) in maternal was 15.7%.Conclusion: Although diagnosis of PPCM is still an exclusion diagnosis, we have to pay more attention to pregnant women complicating with preeclampsia, since preeclampsia can increase the risk of PPCM.
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Susanto et al. (2020) conducted a case-control in Peripartum cardiomyopathy and preeclampsia (n=2,843). Preeclampsia vs. No preeclampsia was evaluated on Peripartum cardiomyopathy (OR 20.679, 95% CI 6.005-71.210, p=<0.0001). Preeclampsia was associated with a significantly increased risk of peripartum cardiomyopathy during pregnancy, with an odds ratio of 20.679.
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