Zika vírus and neurological manifestation: a systematic review

Objective: To determine the main neurological manifestations resulting from human infection by the Zika virus. Methodology: Systematic review of articles published in Science Direct and Scielo, with the following search algorithm: Zika virus and neurological manifestations and diseases of the nervous system. Epidemiological studies reporting neurological disorders related to Zika virus infection were included. Animal studies and systematic reviewswere excluded. Data was extracted and screened by 3 researchers, who agreed on the articles selected. Results: 26 articles were selected in this review, which revealed Guillain-Barré syndrome, microcephaly, encephalitis, meningoencephalitis, myelitis, facial paralysis, congenital alterations, ocular alterations, as well as radiological and electroencephalographic alterations as the main alterations.Conclusion: Zika virus infection has caused a series of neurological alterations in the infected population, whether adults or newborns. The most common condition was Guillain-Barré syndrome, with microcephaly being the most serious as a result of prenatal infection.