Key result
Backbone-modified glutamine compounds potently inhibit human rhinovirus 3C protease at its common cleavage site.
Synthesis of novel inhibitors targeting the human rhinovirus 3C protease using a backbone modified glutamine.
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May support rhinovirus antiviral discovery; leaves open in vivo efficacy and clinical translation.
Based on the common cleavage site (between glutamine and glycine) of the human rhinovirus 3C protease, a series of potent inhibitors of this serine protease containing a backbone modified glutamine has been synthesized.
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Sham et al. (1995) studied this question. Backbone-modified glutamine compounds were synthesized as potent inhibitors of the human rhinovirus 3C protease targeting its common cleavage site.
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