Key result
Left ventricular non-compaction in children was associated with higher LV end-diastolic volume, lower LV ejection fraction, and impaired LV and RV strain compared to controls (all p < 0.05).
Why the study?
LVNC is a rare cardiomyopathy typically involving the LV, but the RV can also be affected, prompting an assessment of both LV and RV morphology and function in children with LVNC.
Does cardiovascular magnetic resonance reveal differences in ventricular morphology and myocardial deformation in children with LVNC compared to healthy controls?
Case-Control (n=32)
Does cardiovascular magnetic resonance reveal differences in ventricular morphology and myocardial deformation in children with LVNC compared to healthy controls?
p-value: p=< 0.05
Children with LVNC exhibit not only left ventricular enlargement and systolic impairment but also increased right ventricular trabeculations and subclinical impairment of right ventricular myocardial deformation.
Background: Left ventricular non-compaction (LVNC) is a rare cardiomyopathy typically involving the left ventricle (LV); however, the right ventricle (RV) can also be affected. This case-control study aimed to assess the morphology and function of LV and RV in children with LVNC. Methods: Sixteen children (13 ± 3 years, six girls) with LVNC were compared with 16 sex- and age-matched controls. LV and RV morphology and function were evaluated in cardiovascular magnetic resonance (CMR) studies. Additionally, LV and RV global radial (GRS), circumferential (GCS), and longitudinal strain (GLS) were assessed using tissue-tracking analysis. Results: Patients with LVNC did not differ from the healthy controls in terms of age, height, weight, and body surface area (BSA). In total, 4/16 subjects with LVNC had mid-wall late gadolinium enhancement (LGE). Compared to the control group, patients with LVNC had higher end-diastolic volume (EDV) indexed for body surface area (BSA), lower ejection fraction (EF), and lower LV strain parameters (all p < 0.05). Children with LVNC also presented with thicker RV apical trabeculation, whereas there were no differences in RV EF and EDV/BSA between the groups. Nevertheless, children with LVNC had impaired RV GRS and GCS (both p < 0.05). Conclusions: LVNC in pediatric patients is associated with LV enlargement and impaired LV systolic function. Additionally, children with LVNC have increased RV trabeculations and subclinical impairment of RV myocardial deformation.
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Sarnecki et al. (2022) conducted a case-control in Left ventricular non-compaction (LVNC) (n=32). Left ventricular non-compaction vs. Healthy age- and sex-matched controls was evaluated on LV and RV morphology and function (p=< 0.05). Left ventricular non-compaction in children was associated with higher LV end-diastolic volume, lower LV ejection fraction, and impaired LV and RV strain compared to controls (all p < 0.05).
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