Clinical review demonstrates the dual role of transfusion therapy in Cooley's anemia, indicating that suppressing erythropoiesis prevents severe complications.
The current approach to transfusion therapy of patients with Cooley's anemia was introduced by Wolman and subStantially modified in the mid 1970s.8-10The goals of transfusion therapy are twofold: to prevent anemia and to maintain a circulating hemoglobin (Hb) level sufficient to 021 15.The publication costs of this article were defrayed in part by page 'uppress endogenous erythropoiesis' The achievement Of erythroid marrow suppression is a major goal Of therapy charge payment, This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. section 1734 solely to because ineffective erythropoiesis (due to unbalanced H b synthesis) leads to many of the disabling complications indicate this fact. 1990 by The American Society ofHematolo0.associated with thalassemia (Table 1).".12
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Fosburg et al. (1990) studied this question.
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