Key result
Youth with ADHD exhibit increased resting BOLD signal variability, indicating an unstable default mode state.
Why the study?
The study sought to determine the nature of resting-state default mode network activation abnormalities and explore its correlation with functional connectivity in ADHD.
Does resting-state BOLD signal variability in the default mode network differ between youth with ADHD and typically developing youth?
Cross-Sectional (n=245)
Yes
Does resting-state BOLD signal variability in the default mode network differ between youth with ADHD and typically developing youth?
Youth with ADHD demonstrate increased intermittent variability in resting-state neural signaling within the default mode network, indicating a more unstable default mode state compared to typically developing youth.
DMN variability may mark ADHD-related instability in youth; hypothesis-generating and requires prospective validation before any clinical role.
In this study, we sought to determine the nature of the abnormality in resting-state default mode network (DMN) activation and explore its correlation with functional connectivity in attention-deficit/hyperactivity disorder (ADHD). We obtained resting-state functional magnetic resonance images of youth with ADHD and typically developing counterparts from the publicly available ADHD-200 database. We used data from Peking University (232 scans) and New York University (172 scans); the scan repetition time was 2 s for both data collection sites. We applied generalized estimating equations to estimate the variability of the averaged blood-oxygen-level-dependent (BOLD) time series extracted from the DMN at rest. We performed network-based statistics to determine the association between the observed differences in BOLD signal variability and altered functional connectivity. We analyzed data from 105 youth with ADHD (age: mean 12.17, standard deviation 2.31, median 12.25; 15.2% female, 84.8% male) and 140 typically developing youth (age: mean 11.99, standard deviation 2.28, median 11.85; 47.1% female, 52.9% male), who aged 7-17 years. The imaging data were cross-sectionally collected for each participant at one time point. We observed a greater number of significant BOLD signal changes and higher-order polynomial significant associations in youth with ADHD. Moreover, there were significant between-group differences in BOLD signal change after the first 140 s, which coincided with decreased resting-state functional connectivity within the DMN in youth with ADHD. Increased variability of neural signaling was intermittently observed in the brains of youth with ADHD at rest, thereby indicating their default mode state was more unstable than that of typically developing youth.
No takes yet. Share an insight, caveat, or question.
Hong et al. (2022) conducted a cross-sectional in Attention-Deficit/Hyperactivity Disorder (ADHD) (n=245). Attention-Deficit/Hyperactivity Disorder (ADHD) vs. Typically developing youth was evaluated on Variability of the averaged blood-oxygen-level-dependent (BOLD) time series extracted from the default mode network (DMN) at rest. Youth with ADHD exhibited increased variability of neural signaling and significant differences in BOLD signal change after the first 140 seconds of rest compared to typically developing youth, indicating a more unstable default mode state.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: