Key result
Copper supplementation restores interleukin-2 production and T-cell counts in copper-deficient rodents.
Why the study?
Does copper supplementation improve interleukin-2 production and T-cell proliferation in copper-deficient rodents?
Does copper supplementation improve interleukin-2 production and T-cell proliferation in copper-deficient rodents?
Copper supplementation reverses impaired interleukin-2 production and T-cell proliferation in copper-deficient rodents.
Answers are grounded in this paper and cite their sources.
Rodent findings do not support copper supplementation in patients; leaves open effects on human interleukin-2 production.
Copper is an essential nutrient for optimal function of the immune system; deficiency results in impairment of both humoral and cell-mediated components. Copper deficiency in rodents results in decreased numbers of CD4+ (helper) and total T cells. This defect has been traced to impaired production of interleukin-2, a cytokine essential for T-cell division and differentiation. Impairment of quiescent cell proliferation is reversed by both in vivo and in vitro copper supplementation.
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Boyd L. O’Dell (2009) conducted a review in Copper deficiency. Copper deficiency was evaluated on Interleukin-2 production and T-cell proliferation. Copper deficiency in rodents impairs interleukin-2 production and decreases T cells, which is reversed by in vivo and in vitro copper supplementation.
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