Key result
Low cardiac output links to ~42% lower 2,3-DPG, introducing errors in calculating in vivo P50.
Why the study?
Is 2,3-diphosphoglycerate (2,3-DPG) concentration altered in patients with low cardiac output, and does it influence the calculation of in vivo P(50)?
Population
13 patients with low cardiac output submitted to cardiopulmonary bypass surgeries without the use of donor…
Comparison
Measurement of 2,3-diphosphoglycerate… vs Normal volunteers and estimated 2,3-DPG (P).
Design
Cohort
Authors
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May bias in vivo P50 estimates using standard 2,3-DPG values in low cardiac output; hypothesis-generating for adjusted calculations in prospective data.
Observational (n=13)
Is 2,3-diphosphoglycerate (2,3-DPG) concentration altered in patients with low cardiac output, and does it influence the calculation of in vivo P(50)?
Absolute Event Rate: 6.9% vs 11.9%
In patients with low cardiac output, 2,3-DPG concentration is reduced, indicating that using standard values for this variable may introduce errors in calculating in vivo P(50).
Piccioni et al. (2003) conducted an observational in Low cardiac output (n=13). Low cardiac output vs. Normal volunteers was evaluated on 2,3-DPG concentration. Patients with low cardiac output had reduced 2,3-DPG concentrations compared to normal volunteers (6.9 vs. 11.9 microm/gHb), which may introduce errors in calculating in vivo P50.
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