Key result
Pregnancy links to a progressively decreased immediate heart rate response to standing vs non-pregnant women.
Why the study?
Autonomic parameters may alter during pregnancy compared to non-pregnant women and require evaluation before therapeutic intervention, with parasympathetic function testing helping predict pre-existing autonomic dysfunction.
Does pregnancy alter the immediate heart rate response to standing compared to non-pregnant women?
Population
Four hundred eighty subjects including non-pregnant women and pregnant women in each trimester in India
Comparison
Pregnant women in each trimester vs non-pregnant women
Design
Case control observational study
Authors
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May indicate altered autonomic function in pregnancy; hypothesis-generating and should not yet change practice.
Case-Control (n=480)
No
Does pregnancy alter the immediate heart rate response to standing compared to non-pregnant women?
p-value: p=<0.05
Pregnancy is associated with a significant decrease in the immediate heart rate response to standing, indicating altered parasympathetic function.
Vikhe et al. (2021) conducted a case-control in Pregnancy (n=480). Pregnancy vs. Non-pregnant women was evaluated on Immediate heart rate response to standing (30:15 ratio) (p=<0.05). Pregnancy was associated with a significant decrease in the immediate heart rate response to standing compared to non-pregnant women (p < 0.05), with the response decreasing further as pregnancy advanced.
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