Key result
2-Amino-4-methylpyridine potently inhibits inducible NO synthase, selectively targeting NOS II over NOS III in rodents.
Population
Mouse RAW 264.7 cells, human recombinant NOS isoforms (I, II, III), and conscious unrestrained rats
Comparison
2-amino-4-methylpyridine vs L-NMMA, L-NIL, aminoguanidine, or untreated…
Design
Preclinical
Authors
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Provides preclinical tool to probe iNOS pathways in rodents; leaves open translation to human cardiovascular disease.
2-amino-4-methylpyridine is a potent, competitive inhibitor of inducible NO synthase with moderate selectivity over endothelial NO synthase in vitro and in vivo.
Faraci et al. (1996) studied this question. 2-amino-4-methylpyridine vs. L-NMMA, L-NIL, and aminoguanidine was evaluated on Inhibition of NOS II activity. 2-Amino-4-methylpyridine is a potent, competitive inhibitor of inducible NO synthase activity in vitro and in vivo, with selectivity for NOS II over NOS III in rodents.
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