In a key step of the synthesis of 8-fluoro anthracycline aglycones such as 7, epoxidation of the electron-poor C8–C9 double bond moiety presented by the 8-acetyl-6,11-dimethoxy-7,10-dihydronaphthacene-5,12-dione starting material can be achieved in high yield and ease of operations using methyl(trifluoromethyl)dioxirane (1b). †Dedicated to Prof. W. Adam (University of Würzburg) on the occasion of his 65th birthday.
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