Key result
Rheumatic fever or cardiac disease carries a 75% long-term rate of rheumatic recurrence.
Cohort (n=3,129)
Rheumatic fever is characterized by a high rate of recurrence, particularly in children between 5 and 14 years of age, with 75% of patients experiencing at least one recurrence over a 13-year period.
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High recurrence rates in pediatric rheumatic heart disease may justify prolonged prophylaxis; leaves open validation in contemporary low-incidence cohorts.
That rheumatic fever or rheumatic cardiac disease is a chronic infectious disease is now generally accepted. In children especially recurrent manifestations of an active inflammatory process are commonly observed. One or more such recurrences took place in 75 per cent of the 3,129 patients studied in this investigation during an average period of thirteen years after the onset of the illness.1Two recurrences were experienced by 51 per cent, three by 32 per cent, four by 20 per cent and five or more by 12 per cent. Although recurrences2of rheumatic activity take place at all ages at which the disease is found, it appears that the largest number occurs between the ages of 5 and 14 years. A curve representing the ages at which reactivations occur shows a sharp decline beginning at the age of 11 or 12. After the age of 20 it resembles a horizontal
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Cohn et al. (1943) conducted a cohort in Rheumatic fever or rheumatic cardiac disease (n=3,129). Rheumatic fever or rheumatic cardiac disease was evaluated on One or more recurrences of rheumatic activity. Over an average of 13 years, 75% of patients with rheumatic fever or rheumatic cardiac disease experienced at least one recurrence of rheumatic activity.
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