Key result
ACS is linked to elevated ADMA, with 100% of acute MI patients showing hyperdimethylargininemia.
Why the study?
The study aimed to comparatively evaluate asymmetric dimethylarginine levels and the frequency of normodimethylargininemia and hyperdimethylargininemia in patients with unstable angina and acute myocardial infarction.
Does the level of asymmetric dimethylarginine (ADMA) differ between patients with unstable angina, acute myocardial infarction, and healthy controls?
Observational (n=124)
Does the level of asymmetric dimethylarginine (ADMA) differ between patients with unstable angina, acute myocardial infarction, and healthy controls?
ADMA levels are significantly elevated in patients with ACS, with higher levels correlating with greater clinical severity such as acute MI, progressive angina, and cardiogenic shock.
The aim of our research work was to study asymmetric dimethylarginine (ADMA) level in a comparative aspect in patients with unstable angina (UA) and acute myocardial infarction (MI) with an analysis of the frequency of normodimethylargininemia (NDAN) and hyperdimethylargininemia (HDAN). In total 104 patients with acute coronary syndrome (ACS) and 20 somatically healthy individuals as a control group were included in the study. From 104 patients with ACS, 63 patients had acute MI, 41 patients had UA. From 41 patients with UA, there were 15 patients with first-time angina and 26 patients with progressive angina. Enzyme-linked immunosorbent assay was used to determine ADMA level. Statistica program version 12.0 was used to data processing. As a result of the study , it was found that the level of ADMA was statistically significantly higher in all patients with ACS compared to somatically healthy individuals. At the same time, the value of the ADMA level in patients with acute MI was statistically significantly higher than in patients with UA, among whom the ADMA level was statistically significantly higher in patients with progressive angina than in patients with first-time angina. Based on the analysis of the frequency of NDAN and HDAN, only 33 % of patients with first-time angina were diagnosed with NDAN. HDAN was detected in 100 % of patients with progressive angina and acute MI. The value of the ADMA level in patients with Q-wave MI was statistically significantly higher than in patients with non Q-wave MI, in patients with complicated MI it was statistically significantly higher than in patients with uncomplicated MI, and in patients with cardiogenic shock it was statistically significantly higher than in patients with pulmonary edema.
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Полунина et al. (2020) conducted an observational in Acute coronary syndrome (unstable angina and acute myocardial infarction) (n=124). Acute coronary syndrome vs. Somatically healthy individuals was evaluated on Asymmetric dimethylarginine (ADMA) level and frequency of hyperdimethylargininemia (HDAN). Acute coronary syndrome was associated with significantly higher asymmetric dimethylarginine levels compared to healthy controls, with hyperdimethylargininemia present in 100% of acute MI patients.
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