Blood Flow Estimation with Harmonic Flash Echo Imaging

Blood volume flow estimation remains an important task for the functional evaluation of internal organs. In vitro and in vivo flow estimation has been carried out using Flash Echo Imaging in harmonic mode after the administration of microbubble-based ultrasound contrast agents. The in vitro flow volume rate correlated with the constant replenishment level but less so with the video intensity decay rate. The in vivo volume flow rates obtained in four dogs agreed well with CVI-Q (time domain correlation) based flow measurement. Our experimental results indicate that the volume flow rate can be accurately estimated in vitro and in vivo using harmonic Flash Echo imaging.